In Sucker Punch, the exciting new movie from Zack Snyder, a young girl has her head swell up so she looks like Mr Mackey from South Park. Retreating to an alternative reality as a coping strategy she imagines herself with a normal size head and a tiny body. It all ends in a madcap chase with bongo music and a surprise guest appearance by the Elephant Man. Three thumbs up!
Thanks to Stefanie! Imdb page in case you are unable to believe this is real.